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Hacker News · Technology

CRISPR takes a bold leap toward silencing Down syndrome's extra chromosome

Article URL: https://medicalxpress.com/news/2026-04-crispr-bold-silencing-syndrome-extra.html Comments URL: https://news.ycombinator.com/item?id=47781286 Points: 28 # Comments: 28

amichail 4 months ago

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Hacker News · Technology

Show HN: Libretto – Making AI browser automations deterministic

Libretto (https://libretto.sh) is a Skill+CLI that makes it easy for your coding agent to generate deterministic browser automations and debug existing ones. Key shift is going from “give an agent a prompt at runtime and hope it figures things out” to: “Use coding agents to generate real scripts yo...

muchael 4 months ago

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Hacker News · Technology

Open Source Isn't Dead. Cal.com Just Learned the Wrong Lesson

Article URL: https://www.strix.ai/blog/cal-com-is-closing-its-code-due-to-ai-threats Comments URL: https://news.ycombinator.com/item?id=47780712 Points: 35 # Comments: 13

bearsyankees 4 months ago

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Hacker News · Technology

Cal.com is going closed source

Article URL: https://cal.com/blog/cal-com-goes-closed-source-why Comments URL: https://news.ycombinator.com/item?id=47780456 Points: 68 # Comments: 88

Benjamin_Dobell 4 months ago

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Hacker News · Technology

The Deepfake Nudes Crisis in Schools Is Worse Than You Thought

Article URL: https://www.wired.com/story/deepfake-nudify-schools-global-crisis/ Comments URL: https://news.ycombinator.com/item?id=47779856 Points: 19 # Comments: 2

smurda 4 months ago

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Hacker News · Technology

Daily Claude outage is upon us. Waiting for Claude Status to update

Article URL: https://claudestatus.com/ Comments URL: https://news.ycombinator.com/item?id=47779730 Points: 135 # Comments: 113

redm 4 months ago

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Hacker News · Technology

Gemini Robotics-ER 1.6

Article URL: https://deepmind.google/blog/gemini-robotics-er-1-6/ Comments URL: https://news.ycombinator.com/item?id=47779094 Points: 13 # Comments: 0

markerbrod 4 months ago

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Hacker News · Technology

Sam Vimes 'Boots' Theory of Socio-Economic Unfairness

Article URL: https://terrypratchett.com/explore-discworld/sam-vimes-boots-theory-of-socio-economic-unfairness/ Comments URL: https://news.ycombinator.com/item?id=47778933 Points: 18 # Comments: 3

latexr 4 months ago

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Hacker News · Technology

US v. Heppner (S.D.N.Y. 2026) no attorney-client privilege for AI chats [pdf]

Article URL: https://fingfx.thomsonreuters.com/gfx/legaldocs/xmvjyjekkpr/Rakoff%20-%20order%20-%20AI.pdf Comments URL: https://news.ycombinator.com/item?id=47778920 Points: 13 # Comments: 6

1vuio0pswjnm7 4 months ago

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Hacker News · Technology

The Future of Everything Is Lies, I Guess: New Jobs

Article URL: https://aphyr.com/posts/419-the-future-of-everything-is-lies-i-guess-new-jobs Comments URL: https://news.ycombinator.com/item?id=47778758 Points: 32 # Comments: 13

aphyr 4 months ago

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Hacker News · Technology

MCP as Observability Interface: Connecting AI Agents to Kernel Tracepoints

Article URL: https://ingero.io/mcp-observability-interface-ai-agents-kernel-tracepoints/ Comments URL: https://news.ycombinator.com/item?id=47778617 Points: 16 # Comments: 4

ingero_io 4 months ago

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Hacker News · Technology

God Sleeps in the Minerals

Article URL: https://wchambliss.wordpress.com/2026/03/03/god-sleeps-in-the-minerals/ Comments URL: https://news.ycombinator.com/item?id=47778475 Points: 71 # Comments: 18

speckx 4 months ago

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Hacker News · Technology

US national level OS-level age verification bill

Article URL: https://social.coop/@cwebber/116408556882122186 Comments URL: https://news.ycombinator.com/item?id=47778366 Points: 53 # Comments: 30

marvinborner 4 months ago

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Hacker News · Technology

AI ruling prompts warnings from US lawyers: Your chats could be used against you

Article URL: https://www.reuters.com/legal/government/ai-ruling-prompts-warnings-us-lawyers-your-chats-could-be-used-against-you-2026-04-15/ Comments URL: https://news.ycombinator.com/item?id=47778308 Points: 25 # Comments: 3

alephnerd 4 months ago

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Hacker News · Technology

Show HN: Every CEO and CFO change at US public companies, live from SEC

Built this solo. It watches SEC filings for executive and board changes, extracts the data, and shows it in real time. 2,100+ changes in the last 30 days. The comp data is interesting: average new CEO total comp is $8.4M across 284 appointments. The /explore page is fully open, no login needed. Co...

porsche959 4 months ago

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Hacker News · Technology

Show HN: Pseudonymizing sensitive data for LLMs without losing context

Article URL: https://atticsecurity.com/en/blog/why-llms-hate-fake-data-token-proxy/ Comments URL: https://news.ycombinator.com/item?id=47778087 Points: 3 # Comments: 2

n00pn00p 4 months ago

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Hacker News · Technology

Do you even need a database?

Article URL: https://www.dbpro.app/blog/do-you-even-need-a-database Comments URL: https://news.ycombinator.com/item?id=47778086 Points: 26 # Comments: 39

upmostly 4 months ago

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Hacker News · Technology

Study: Back-to-basics approach can match or outperform AI in language analysis

Article URL: https://www.manchester.ac.uk/about/news/back-to-basics-approach-can-match-or-outperform-ai/ Comments URL: https://news.ycombinator.com/item?id=47778050 Points: 7 # Comments: 0

giuliomagnifico 4 months ago

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Hacker News · Technology

Proliferate (YC S25) Is Hiring Founding Engineers

Article URL: https://www.ycombinator.com/companies/proliferate/jobs/L3copvK-founding-engineer Comments URL: https://news.ycombinator.com/item?id=47777902 Points: 0 # Comments: 0

pablo24602 4 months ago

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Hacker News · Technology

Retrofitting JIT Compilers into C Interpreters

Article URL: https://tratt.net/laurie/blog/2026/retrofitting_jit_compilers_into_c_interpreters.html Comments URL: https://news.ycombinator.com/item?id=47777897 Points: 33 # Comments: 9

ltratt 4 months ago

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Hacker News · Technology

New bill would let New Yorkers hang solar panels from windows

Article URL: https://gothamist.com/news/here-comes-the-sun-new-bill-would-let-new-yorkers-hang-solar-panels-from-windows Comments URL: https://news.ycombinator.com/item?id=47777882 Points: 26 # Comments: 21

geox 4 months ago

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Hacker News · Technology

Academic fraud may be the symptom of a more systemic problem

Article URL: https://www.voxweb.nl/en/academic-fraud-may-be-the-symptom-of-a-much-more-systemic-problem Comments URL: https://news.ycombinator.com/item?id=47777449 Points: 18 # Comments: 0

the-mitr 4 months ago

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Hacker News · Technology

Your Backpack Got Worse on Purpose

Article URL: https://www.worseonpurpose.com/p/your-backpack-got-worse-on-purpose Comments URL: https://news.ycombinator.com/item?id=47777209 Points: 73 # Comments: 38

113 4 months ago

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Hacker News · Technology

Want to Write a Compiler? Just Read These Two Papers (2008)

Article URL: https://prog21.dadgum.com/30.html Comments URL: https://news.ycombinator.com/item?id=47776796 Points: 36 # Comments: 9

downbad_ 4 months ago

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